Modelling of high salt intake effect on renal interstitial fibrosis

Abstract

Renal fibrosis is the deposition of extracellular matrix (ECM) in the kidney, during tissue repair or as a response to inflammation. Nowadays, renal failure and specially renal fibrosis diagnosis are increasing in Paraguay and the cause is not clear yet. However, there are strong evidences that high dietary intake of salt promotes the fibrogenic process by unclear mechanisms [3]. This work is part of a more a ambitious one to develop a mathematical model to simulate the progression of renal interstitial fibrosis under different salt concentrations. To this end, a previous model for renal fibrosis from the literature [4] is modified to consider salt concentration. A flow chart is shown in Figure 1.