Uncertainty analysis in mass transfer parameter estimations for chromatographic separation of glucose and fructose

Abstract

In this paper, a statistical approach for the analysis of the propagation of uncertainty is shown, in the estimate of the kinetic parameters of mass transference used to model a chromatographic column in Simulated Moving Bed. The modeling of the chromatography column was accomplished intervening the new approach front velocity. The analysis of how it is propagated the operational factors uncertainty involved in the process of chromatography toward the estimated parameters was carried out by the use of response surface methodology. Furthermore, chromatographic regions where factors cause bigger variation in the output and their respective patterns were determined. The analysis was applied to the separation process of glucose and fructose.